Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice with a null mutation in C/EBPɛ develop normally and are fertile but fail to generate functional neutrophi...

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Detalhes bibliográficos
Main Authors: Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, Decker, Thomas, Wynshaw-Boris, Anthony, Xanthopoulos, Kleanthis G.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24284/
https://ncbi.nlm.nih.gov/pubmed/9371821
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