RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

The gene encoding the RUNX1 transcription factor is mutated in a subset of T-cell acute lymphoblastic leukemia (T-ALL) patients, and RUNX1 mutations are associated with a poor prognosis. These mutations cluster in the DNA-binding Runt domain and are thought to represent loss-of-function mutations, i...

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Veröffentlicht in:Blood
Hauptverfasser: Choi, AHyun, Illendula, Anuradha, Pulikkan, John A., Roderick, Justine E., Tesell, Jessica, Yu, Jun, Hermance, Nicole, Zhu, Lihua Julie, Castilla, Lucio H., Bushweller, John H., Kelliher, Michelle A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639483/
https://ncbi.nlm.nih.gov/pubmed/28790107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-775536
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