c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-ALL), 20% to 30% of patients undergo induction failure (IF) or relapse. Leukemia-initiating cells (LICs) are hypothesized to be resistant to chemotherapy and to mediate relapse. We and others have shown that Not...

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Detalhes bibliográficos
Main Authors: Roderick, Justine E., Tesell, Jessica, Shultz, Leonard D., Brehm, Michael A., Greiner, Dale L., Harris, Marian H., Silverman, Lewis B., Sallan, Stephen E., Gutierrez, Alejandro, Look, A. Thomas, Qi, Jun, Bradner, James E., Kelliher, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924926/
https://ncbi.nlm.nih.gov/pubmed/24394663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-522698
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