Prostaglandin E(2) stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death

Glucocorticoid (GC) resistance remains a clinical challenge in pediatric acute lymphoblastic leukemia where response to GC is a reliable prognostic indicator. To identify GC resistance pathways, we conducted a genome-wide, survival-based, short hairpin RNA screen in murine T-cell acute lymphoblastic...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Roderick, Justine E., Gallagher, Kayleigh M., Murphy, Leonard C., O’Connor, Kevin W., Tang, Katherine, Zhang, Boyao, Brehm, Michael A., Greiner, Dale L., Yu, Jun, Zhu, Lihua Julie, Green, Michael R., Kelliher, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845005/
https://ncbi.nlm.nih.gov/pubmed/33507291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005712
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