Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia

Glucocorticoids (GCs), including dexamethasone (dex), are a central component of combination chemotherapy for childhood B-cell precursor acute lymphoblastic leukemia (B-ALL). GCs work by activating the GC receptor (GR), a ligand-induced transcription factor, which in turn regulates genes that induce...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Kruth, Karina A., Fang, Mimi, Shelton, Dawne N., Abu-Halawa, Ossama, Mahling, Ryan, Yang, Hongxing, Weissman, Jonathan S., Loh, Mignon L., Müschen, Markus, Tasian, Sarah K., Bassik, Michael C., Kampmann, Martin, Pufall, Miles A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454339/
https://ncbi.nlm.nih.gov/pubmed/28424165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-766204
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