Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia

Glucocorticoids (GCs) are used in combination chemotherapies as front-line treatment for B cell acute lymphoblastic leukemia (B-ALL). Although effective, many patients relapse and become resistant to chemotherapy and GCs in particular. Why these patients relapse is not clear. We took a comprehensive...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Poulard, Coralie, Kim, Hye Na, Fang, Mimi, Kruth, Karina, Gagnieux, Celine, Gerke, Daniel S., Bhojwani, Deepa, Kim, Yong-Mi, Kampmann, Martin, Stallcup, Michael R., Pufall, Miles A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386662/
https://ncbi.nlm.nih.gov/pubmed/30733284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816254116
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