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Prostaglandin E(2) stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death

Glucocorticoid (GC) resistance remains a clinical challenge in pediatric acute lymphoblastic leukemia where response to GC is a reliable prognostic indicator. To identify GC resistance pathways, we conducted a genome-wide, survival-based, short hairpin RNA screen in murine T-cell acute lymphoblastic...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Roderick, Justine E., Gallagher, Kayleigh M., Murphy, Leonard C., O’Connor, Kevin W., Tang, Katherine, Zhang, Boyao, Brehm, Michael A., Greiner, Dale L., Yu, Jun, Zhu, Lihua Julie, Green, Michael R., Kelliher, Michelle A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845005/
https://ncbi.nlm.nih.gov/pubmed/33507291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005712
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