Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia

Treatment resistance in T-cell acute lymphoblastic leukemia (T-ALL) is associated with PTEN deletions and resultant PI3K-AKT pathway activation, as well as MYC overexpression, and these pathways repress mitochondrial apoptosis in established T-lymphoblasts through poorly defined mechanisms. Normal T...

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Detalhes bibliográficos
Main Authors: Reynolds, Christine, Roderick, Justine E., LaBelle, James L., Bird, Gregory, Mathieu, Ronald, Bodaar, Kimberly, Colon, Diana, Pyati, Ujwal, Stevenson, Kristen E., Qi, Jun, Harris, Marian, Silverman, Lewis B., Sallan, Stephen E., Bradner, James E., Neuberg, Donna S., Look, A. Thomas, Walensky, Loren D., Kelliher, Michelle A., Gutierrez, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139485/
https://ncbi.nlm.nih.gov/pubmed/24552990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.78
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