Bim polymorphisms: influence on function and response to treatment in children with acute lymphoblastic leukemia

PURPOSE: Corticosteroids (CS) induce apoptosis in the malignant lymphoid cells and are critical component of combination therapy for acute lymphoblastic leukemia (ALL). Several genome-wide microarray studies demonstrated major implication of proapoptotic Bim in mediating CS-related resistance in leu...

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Hauptverfasser: Gagné, Vincent, Rousseau, Julie, Labuda, Malgorzata, Sharif-Askari, Bahram, Brukner, Ivan, Laverdière, Caroline, Ceppi, Francesco, Sallan, Stephen E., Silverman, Lewis B., Neuberg, Donna, Kutok, Jeffery L., Sinnett, Daniel, Krajinovic, Maja
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128417/
https://ncbi.nlm.nih.gov/pubmed/23908358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1215
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