CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

Recent studies suggest that the chromosome 16 inversion, associated with acute myeloid leukemia M4Eo, takes place in hematopoietic stem cells. If this is the case, it is of interest to know the effects of the resulting fusion gene, CBFB-MYH11, on other lineages. Here we studied T-cell development in...

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Detalhes bibliográficos
Main Authors: Zhao, Ling, Cannons, Jennifer L., Anderson, Stacie, Kirby, Martha, Xu, Liping, Castilla, Lucio H., Schwartzberg, Pamela L., Bosselut, Rémy, Liu, P. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852246/
https://ncbi.nlm.nih.gov/pubmed/17185462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-051508
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