Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11

Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. Previous studies showed that the interaction between CBFβ-smooth muscle myosin heavy chain (SMMHC; encoded by CBFB-MYH11) and RUNX1 plays...

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Bibliographic Details
Published in:Blood
Main Authors: Zhen, Tao, Kwon, Erika M., Zhao, Ling, Hsu, Jingmei, Hyde, R. Katherine, Lu, Ying, Alemu, Lemlem, Speck, Nancy A., Liu, P. Paul
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709785/
https://ncbi.nlm.nih.gov/pubmed/29018080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-04-780106
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