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Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knockin mice
CBFβ-SMMHC, the fusion protein generated by the chromosome 16 inversion fusion gene, CBFB-MYH11, is known to initiate leukemogenesis. However, the mechanism through which CBFβ-SMMHC contributes to leukemia development is not well understood. Previously it was proposed that CBFβ-SMMHC acts by dominan...
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| Publicado no: | Leukemia |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526349/ https://ncbi.nlm.nih.gov/pubmed/25742748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.58 |
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