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Cbfb/Runx1 repression–independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11

It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transformation. However, the mechanism by which CBFB-MYH11 initiates leukemogenesis is not clear. Previously published reports showed that CBFB-MYH11 domin...

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Autores principales: Hyde, R. Katherine, Kamikubo, Yasuhiko, Anderson, Stacie, Kirby, Martha, Alemu, Lemlem, Zhao, Ling, Liu, P. Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826765/
https://ncbi.nlm.nih.gov/pubmed/20007544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-227413
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