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The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis
The C-terminus of CBFβ-SMMHC, the fusion protein produced by a chromosome 16 inversion in acute myeloid leukemia subtype M4Eo, contains domains for self-multimerization and transcriptional repression, both of which have been proposed to be important for leukemogenesis by CBFβ-SMMHC. To test the role...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557645/ https://ncbi.nlm.nih.gov/pubmed/23152542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-434688 |
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