The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

The mixed-lineage leukemia (MLL) H3K4 methyltransferase protein, and the heterodimeric RUNX1/CBFβ transcription factor complex, are critical for definitive and adult hematopoiesis, and both are frequently targeted in human acute leukemia. We identified a physical and functional interaction between R...

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Détails bibliographiques
Auteurs principaux: Huang, Gang, Zhao, Xinghui, Wang, Lan, Elf, Shannon, Xu, Hao, Zhao, Xinyang, Sashida, Goro, Zhang, Yue, Liu, Yan, Lee, Jennifer, Menendez, Silvia, Yang, Youyang, Yan, Xiaomei, Zhang, Pu, Tenen, Daniel G., Osato, Motomi, Hsieh, James J.-D., Nimer, Stephen D.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Hematopoiesis and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242717/
https://ncbi.nlm.nih.gov/pubmed/22012064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-317909
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