Species Selectivity of Mixed-Lineage Leukemia/Trithorax and HCF Proteolytic Maturation Pathways

door Capotosti, Francesca, Hsieh, James J.-D., Herr, Winship
Gepubliceerd in 2007

Bimodal degradation of MLL by SCF(Skp2) and APC(Cdc20) assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

door Liu, Han, Cheng, Emily H.-Y., Hsieh, James J.-D.
Gepubliceerd in 2007

A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters

door Zhou, Sifang, Fujimuro, Masahiro, Hsieh, James J.-D., Chen, Lin, Hayward, S. Diane
Gepubliceerd in 2000

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

door Hsieh, James J.-D., Zhou, Sifang, Chen, Lin, Young, David B., Hayward, S. Diane
Gepubliceerd in 1999

Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization

door Hsieh, James J.-D., Ernst, Patricia, Erdjument-Bromage, Hediye, Tempst, Paul, Korsmeyer, Stanley J.
Gepubliceerd in 2003

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

door Zhou, Sifang, Fujimuro, Masahiro, Hsieh, James J.-D., Chen, Lin, Miyamoto, Alison, Weinmaster, Gerry, Hayward, S. Diane
Gepubliceerd in 2000

Design, syntheses, and evaluation of Taspase1 inhibitors

door Lee, Jeong Tae, Chen, David Y., Yang, Zhimou, Ramos, Alexander D., Hsieh, James J.-D., Bogyo, Matthew
Gepubliceerd in 2009

Uncleaved TFIIA Is a Substrate for Taspase 1 and Active in Transcription

door Zhou, Huiqing, Spicuglia, Salvatore, Hsieh, James J.-D., Mitsiou, Dimitra J., Høiby, Torill, Veenstra, Gert Jan C., Korsmeyer, Stanley J., Stunnenberg, Hendrik G.
Gepubliceerd in 2006

Phosphorylation of MLL by ATR is Required for Execution of Mammalian S Phase Checkpoint

door Liu, Han, Takeda, Shugaku, Kumar, Rakesh, Westergard, Todd D., Brown, Eric J., Pandita, Tej K., Cheng, Emily H.-Y., Hsieh, James J.-D.
Gepubliceerd in 2010

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

door Kim, Hyungjin, Tu, Ho-Chou, Ren, Decheng, Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Gepubliceerd in 2009

Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer

door Vanharanta, Sakari, Shu, Weiping, Brenet, Fabienne, Hakimi, A. Ari, Heguy, Adriana, Viale, Agnes, Reuter, Victor E., Hsieh, James J.-D., Scandura, Joseph M., Massagué, Joan
Gepubliceerd in 2012

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

door Tu, Ho-Chou, Ren, Decheng, Wang, Gary X., Chen, David Y., Westergard, Todd D., Kim, Hyungjin, Sasagawa, Satoru, Hsieh, James J.-D., Cheng, Emily H.-Y.
Gepubliceerd in 2009

Taspase1 Functions as a Non-oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis

door Chen, David Y., Liu, Han, Takeda, Shugaku, Tu, Ho-Chou, Sasagawa, Satoru, Van Tine, Brian A., Lu, Dongsi, Cheng, Emily H.-Y., Hsieh, James J.-D.
Gepubliceerd in 2010

The VDAC2-BAK Rheostat Controls Thymocyte Survival

door Ren, Decheng, Kim, Hyungjin, Tu, Ho-Chou, Westergard, Todd D., Fisher, Jill K., Rubens, Jeff A., Korsmeyer, Stanley J., Hsieh, James J.-D., Cheng, Emily H.-Y.
Gepubliceerd in 2009

Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression

door Takeda, Shugaku, Chen, David Y., Westergard, Todd D., Fisher, Jill K., Rubens, Jeffrey A., Sasagawa, Satoru, Kan, Jason T., Korsmeyer, Stanley J., Cheng, Emily H.-Y., Hsieh, James J.-D.
Gepubliceerd in 2006

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

door Ren, Decheng, Tu, Ho-Chou, Kim, Hyungjin, Wang, Gary X., Bean, Gregory R., Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Gepubliceerd in 2010

PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis

door Bean, Gregory R., Ganesan, Yogesh Tengarai, Dong, Yiyu, Takeda, Shugaku, Liu, Han, Chan, Po M., Huang, Yafen, Chodosh, Lewis A., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Gepubliceerd in 2013

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

door Huang, Gang, Zhao, Xinghui, Wang, Lan, Elf, Shannon, Xu, Hao, Zhao, Xinyang, Sashida, Goro, Zhang, Yue, Liu, Yan, Lee, Jennifer, Menendez, Silvia, Yang, Youyang, Yan, Xiaomei, Zhang, Pu, Tenen, Daniel G., Osato, Motomi, Hsieh, James J.-D., Nimer, Stephen D.
Gepubliceerd in 2011

A Pharmacological Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

door Chen, David Y., Lee, Yishan, Van Tine, Brian A., Searleman, Adam C., Westergard, Todd D., Liu, Han, Tu, Ho-Chou, Takeda, Shugaku, Dong, Yiyu, Piwnica-Worms, David R., Oh, Kyoung J., Korsmeyer, Stanley J., Hermone, Ann, Gussio, Richard, Shoemaker, Robert H., Cheng, Emily H.-Y., Hsieh, James J.-D.
Gepubliceerd in 2011