Bimodal degradation of MLL by SCF(Skp2) and APC(Cdc20) assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

Human chromosome 11q23 translocations disrupting MLL result in poor prognostic leukemias. It fuses the common MLL N-terminal ∼1400 amino acids in-frame with >60 different partners without shared characteristics. In addition to the well-characterized activity of MLL in maintaining Hox gene express...

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Bibliographic Details
Main Authors: Liu, Han, Cheng, Emily H.-Y., Hsieh, James J.-D.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1993870/
https://ncbi.nlm.nih.gov/pubmed/17908926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1574507
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