Lanean...
Bimodal degradation of MLL by SCF(Skp2) and APC(Cdc20) assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions
Human chromosome 11q23 translocations disrupting MLL result in poor prognostic leukemias. It fuses the common MLL N-terminal ∼1400 amino acids in-frame with >60 different partners without shared characteristics. In addition to the well-characterized activity of MLL in maintaining Hox gene express...
Gorde:
| Egile Nagusiak: | , , |
|---|---|
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Cold Spring Harbor Laboratory Press
2007
|
| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1993870/ https://ncbi.nlm.nih.gov/pubmed/17908926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1574507 |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|