BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in vivo evidence demonstrating an essential role of the proteins BID, BIM, and PUMA in activating BAX and BAK. Bid, Bim, and Puma triple-knockou...

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Detalhes bibliográficos
Main Authors: Ren, Decheng, Tu, Ho-Chou, Kim, Hyungjin, Wang, Gary X., Bean, Gregory R., Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163443/
https://ncbi.nlm.nih.gov/pubmed/21127253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190217
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