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BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the Bcl-2 family, known as the BH3-only proteins, activate pro-apoptotic effectors (Bax and Bak) to initiate MOMP. They do so by neutralizing pro-...

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Detalhes bibliográficos
Main Authors: Du, Han, Wolf, Jacob, Schafer, Blanca, Moldoveanu, Tudor, Chipuk, Jerry E., Kuwana, Tomomi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013008/
https://ncbi.nlm.nih.gov/pubmed/21041309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167148
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