Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax

The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce conformation change, oligomerization and pore formation in mito...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Hockings, C, Anwari, K, Ninnis, R L, Brouwer, J, O'Hely, M, Evangelista, M, Hinds, M G, Czabotar, P E, Lee, E F, Fairlie, W D, Dewson, G, Kluck, R M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650538/
https://ncbi.nlm.nih.gov/pubmed/25906158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.105
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