Mcl-1 and Bcl-x(L) sequestration of Bak confers differential resistance to BH3-only proteins

The prosurvival Bcl-2 family proteins Mcl-1 and Bcl-x(L) inhibit apoptosis by sequestering BH3-only proteins such as Bid and Bim (MODE 1) or the effector proteins Bak and Bax (MODE 2). To better understand the contributions of MODE 1 and MODE 2 in blocking cell death, and thus how to bypass resistan...

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Pubblicato in:Cell Death Differ
Autori principali: Hockings, Colin, Alsop, Amber E., Fennell, Stephanie C., Lee, Erinna F., Fairlie, W. Douglas, Dewson, Grant, Kluck, Ruth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864222/
https://ncbi.nlm.nih.gov/pubmed/29459767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0010-6
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