BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

BAK and BAX are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. BAK and BAX undergo conformation changes to homooligomerize then permeabilize the mitochondrial outer membrane during apoptosis. How BCL-2 homology 3 (BH3)-only proteins bind to a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530671/
https://ncbi.nlm.nih.gov/pubmed/28673969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702453114
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