Assembly of the Bak Apoptotic Pore: A CRITICAL ROLE FOR THE BAK PROTEIN α6 HELIX IN THE MULTIMERIZATION OF HOMODIMERS DURING APOPTOSIS

Bak and Bax are the essential effectors of the intrinsic pathway of apoptosis. Following an apoptotic stimulus, both undergo significant changes in conformation that facilitates their self-association to form pores in the mitochondrial outer membrane. However, the molecular structures of Bak and Bax...

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Autors principals: Ma, Stephen, Hockings, Colin, Anwari, Khatira, Kratina, Tobias, Fennell, Stephanie, Lazarou, Michael, Ryan, Michael T., Kluck, Ruth M., Dewson, Grant
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764807/
https://ncbi.nlm.nih.gov/pubmed/23893415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490094
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