Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2 (Bcl-2) family members Bak or Bax. However, how they disrupt MOM integrity is unknown. A longstanding model is that activated Bak and Bax ins...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Westphal, Dana, Dewson, Grant, Menard, Marie, Frederick, Paul, Iyer, Sweta, Bartolo, Ray, Gibson, Leonie, Czabotar, Peter E., Smith, Brian J., Adams, Jerry M., Kluck, Ruth M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191798/
https://ncbi.nlm.nih.gov/pubmed/25228770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415142111
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky