Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2 (Bcl-2) family members Bak or Bax. However, how they disrupt MOM integrity is unknown. A longstanding model is that activated Bak and Bax ins...

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Bibliografiska uppgifter
Huvudupphovsmän: Westphal, Dana, Dewson, Grant, Menard, Marie, Frederick, Paul, Iyer, Sweta, Bartolo, Ray, Gibson, Leonie, Czabotar, Peter E., Smith, Brian J., Adams, Jerry M., Kluck, Ruth M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191798/
https://ncbi.nlm.nih.gov/pubmed/25228770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415142111
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