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Bak apoptotic function is not directly regulated by phosphorylation
During apoptosis, Bak and Bax permeabilize the mitochondrial outer membrane by undergoing major conformational change and oligomerization. This activation process in Bak is reported to require dephosphorylation of tyrosine-108 close to an activation trigger site. To investigate how dephosphorylation...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563979/ https://ncbi.nlm.nih.gov/pubmed/23303126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.191 |
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