Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

Bak and Bax mediate apoptotic cell death by oligomerizing and forming a pore in the mitochondrial outer membrane. Both proteins anchor to the outer membrane via a C-terminal transmembrane domain, although its topology within the apoptotic pore is not known. Cysteine-scanning mutagenesis and hydrophi...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: Iyer, S, Bell, F, Westphal, D, Anwari, K, Gulbis, J, Smith, B J, Dewson, G, Kluck, R M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563781/
https://ncbi.nlm.nih.gov/pubmed/25744027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.15
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