Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

gan Dewson, Grant, Kluck, Ruth M.
Cyhoeddwyd 2009

Pore formation by dimeric Bak and Bax: an unusual pore?

gan Uren, Rachel T., Iyer, Sweta, Kluck, Ruth M.
Cyhoeddwyd yn Philos Trans R Soc Lond B Biol Sci (2017)

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation

gan Hockings, Colin, Iyer, Sweta, Uren, Rachel T., Kluck, Ruth M.
Cyhoeddwyd yn Cell Death Differ (2019)

Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

gan Ferrer, Pedro Eitz, Frederick, Paul, Gulbis, Jacqueline M., Dewson, Grant, Kluck, Ruth M.
Cyhoeddwyd 2012

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

gan von Ahsen, Oliver, Renken, Christian, Perkins, Guy, Kluck, Ruth M., Bossy-Wetzel, Ella, Newmeyer, Donald D.
Cyhoeddwyd 2000

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

gan Uren, Rachel T., Dewson, Grant, Chen, Lin, Coyne, Stephanie C., Huang, David C.S., Adams, Jerry M., Kluck, Ruth M.
Cyhoeddwyd 2007

Assembly of the Bak Apoptotic Pore: A CRITICAL ROLE FOR THE BAK PROTEIN α6 HELIX IN THE MULTIMERIZATION OF HOMODIMERS DURING APOPTOSIS

gan Ma, Stephen, Hockings, Colin, Anwari, Khatira, Kratina, Tobias, Fennell, Stephanie, Lazarou, Michael, Ryan, Michael T., Kluck, Ruth M., Dewson, Grant
Cyhoeddwyd 2013

Mcl-1 and Bcl-x(L) sequestration of Bak confers differential resistance to BH3-only proteins

gan Hockings, Colin, Alsop, Amber E., Fennell, Stephanie C., Lee, Erinna F., Fairlie, W. Douglas, Dewson, Grant, Kluck, Ruth M.
Cyhoeddwyd yn Cell Death Differ (2018)

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

gan Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.
Cyhoeddwyd yn Cell Death Dis (2020)

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

gan Fleming, Peter, Kvansakul, Marc, Voigt, Valentina, Kile, Benjamin T., Kluck, Ruth M., Huang, David C. S., Degli-Esposti, Mariapia A., Andoniou, Christopher E.
Cyhoeddwyd 2013

Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

gan Lazarou, Michael, Stojanovski, Diana, Frazier, Ann E., Kotevski, Aneta, Dewson, Grant, Craigen, William J., Kluck, Ruth M., Vaux, David L., Ryan, Michael T.
Cyhoeddwyd 2010

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

gan Uren, Rachel T, O’Hely, Martin, Iyer, Sweta, Bartolo, Ray, Shi, Melissa X, Brouwer, Jason M, Alsop, Amber E, Dewson, Grant, Kluck, Ruth M
Cyhoeddwyd yn eLife (2017)

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

gan Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2017)

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

gan Westphal, Dana, Dewson, Grant, Menard, Marie, Frederick, Paul, Iyer, Sweta, Bartolo, Ray, Gibson, Leonie, Czabotar, Peter E., Smith, Brian J., Adams, Jerry M., Kluck, Ruth M.
Cyhoeddwyd 2014

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

gan Yeo, Janet H. C., Skinner, Jarrod P. J., Bird, Matthew J., Formosa, Luke E., Zhang, Jian-Guo, Kluck, Ruth M., Belz, Gabrielle T., Chong, Mark M. W.
Cyhoeddwyd yn PLoS One (2015)

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

gan Iyer, Sweta, Anwari, Khatira, Alsop, Amber E., Yuen, Wai Shan, Huang, David C. S., Carroll, John, Smith, Nicholas A., Smith, Brian J., Dewson, Grant, Kluck, Ruth M.
Cyhoeddwyd yn Nat Commun (2016)

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

gan Brasacchio, Daniella, Alsop, Amber E, Noori, Tahereh, Lufti, Mariam, Iyer, Sweta, Simpson, Kaylene J, Bird, Phillip I, Kluck, Ruth M, Johnstone, Ricky W, Trapani, Joseph A
Cyhoeddwyd yn Cell Death Differ (2017)

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

gan Kluck, Ruth M., Esposti, Mauro Degli, Perkins, Guy, Renken, Christian, Kuwana, Tomomi, Bossy-Wetzel, Ella, Goldberg, Martin, Allen, Terry, Barber, Michael J., Green, Douglas R., Newmeyer, Donald D.
Cyhoeddwyd 1999

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

gan Slee, Elizabeth A., Harte, Mary T., Kluck, Ruth M., Wolf, Beni B., Casiano, Carlos A., Newmeyer, Donald D., Wang, Hong-Gang, Reed, John C., Nicholson, Donald W., Alnemri, Emad S., Green, Douglas R., Martin, Seamus J.
Cyhoeddwyd 1999

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect.

gan Abdullaev, Ziedulla Kh, Bodrova, Marina E, Chernyak, Boris V, Dolgikh, Dmitry A, Kluck, Ruth M, Pereverzev, Mikhail O, Arseniev, Alexander S, Efremov, Roman G, Kirpichnikov, Mikhail P, Mokhova, Elena N, Newmeyer, Donald D, Roder, Heinrich, Skulachev, Vladimir P
Cyhoeddwyd 2002