Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

BAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangements. One crucial conformation change is exposure of their BH3 domain which allows BAK or BAX to form homodimers, and potentially to autoactivate other...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181796/
https://ncbi.nlm.nih.gov/pubmed/32327636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2463-7
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