Disordered clusters of Bak dimers rupture mitochondria during apoptosis

During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondria. This comprehensive sur...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Uren, Rachel T, O’Hely, Martin, Iyer, Sweta, Bartolo, Ray, Shi, Melissa X, Brouwer, Jason M, Alsop, Amber E, Dewson, Grant, Kluck, Ruth M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302884/
https://ncbi.nlm.nih.gov/pubmed/28182867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19944
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