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Disordered clusters of Bak dimers rupture mitochondria during apoptosis

During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondria. This comprehensive sur...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Uren, Rachel T, O’Hely, Martin, Iyer, Sweta, Bartolo, Ray, Shi, Melissa X, Brouwer, Jason M, Alsop, Amber E, Dewson, Grant, Kluck, Ruth M
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302884/
https://ncbi.nlm.nih.gov/pubmed/28182867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19944
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