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Disordered clusters of Bak dimers rupture mitochondria during apoptosis

During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondria. This comprehensive sur...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Uren, Rachel T, O’Hely, Martin, Iyer, Sweta, Bartolo, Ray, Shi, Melissa X, Brouwer, Jason M, Alsop, Amber E, Dewson, Grant, Kluck, Ruth M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302884/
https://ncbi.nlm.nih.gov/pubmed/28182867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19944
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