The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

During apoptosis, an important pathway leading to caspase activation involves the release of cytochrome c from the intermembrane space of mitochondria. Using a cell-free system based on Xenopus egg extracts, we examined changes in the outer mitochondrial membrane accompanying cytochrome c efflux. Th...

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Autori principali: Kluck, Ruth M., Esposti, Mauro Degli, Perkins, Guy, Renken, Christian, Kuwana, Tomomi, Bossy-Wetzel, Ella, Goldberg, Martin, Allen, Terry, Barber, Michael J., Green, Douglas R., Newmeyer, Donald D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1999
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156156/
https://ncbi.nlm.nih.gov/pubmed/10562282
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