Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm. The BCL-2–associated X apoptosis regulator (BAX) protein critically contributes to this process by forming...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kuwana, Tomomi, King, Louise E., Cosentino, Katia, Suess, Julian, Garcia-Saez, Ana J., Gilmore, Andrew P., Newmeyer, Donald D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008371/
https://ncbi.nlm.nih.gov/pubmed/31901077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011635
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