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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

Bax promotes cell death by permeabilizing mitochondrial outer membranes by an unresolved mechanism. However, in cells lacking the gene c-myc, membrane permeabilization by Bax is blocked by changes in the mitochondria that prevent Bax oligomerization. Drug-treated c-myc null cells and cells expressin...

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Autors principals: Annis, Matthew G, Soucie, Erinn L, Dlugosz, Paulina J, Cruz-Aguado, Jorge A, Penn, Linda Z, Leber, Brian, Andrews, David W
Format: Artigo
Idioma:Inglês
Publicat: 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150878/
https://ncbi.nlm.nih.gov/pubmed/15920484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600675
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