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Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species
Bax is a key regulator of apoptosis that mediates the release of cytochrome c to the cytosol via oligomerization in the outer mitochondrial membrane before pore formation. However, the molecular mechanism of Bax assembly and regulation by other Bcl-2 members remains obscure. Here, by analysing the s...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Pub. Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4557355/ https://ncbi.nlm.nih.gov/pubmed/26271728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9042 |
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