Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

Bax is a key regulator of apoptosis that mediates the release of cytochrome c to the cytosol via oligomerization in the outer mitochondrial membrane before pore formation. However, the molecular mechanism of Bax assembly and regulation by other Bcl-2 members remains obscure. Here, by analysing the s...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Subburaj, Yamunadevi, Cosentino, Katia, Axmann, Markus, Pedrueza-Villalmanzo, Esteban, Hermann, Eduard, Bleicken, Stephanie, Spatz, Joachim, García-Sáez, Ana J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557355/
https://ncbi.nlm.nih.gov/pubmed/26271728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9042
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