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Bax and Bak Pores: Are We Closing the Circle?

Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. On cell stress Bax and Bak accumulate at distinct foci on the mitochondrial surface where they undergo a conformational change, oligomerize, and mediate cytochrome c release, leading to cell death. The molecular me...

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Bibliografische gegevens
Gepubliceerd in:Trends Cell Biol
Hoofdauteurs: Cosentino, Katia, García-Sáez, Ana J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898608/
https://ncbi.nlm.nih.gov/pubmed/27932064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2016.11.004
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