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Bax and Bak Pores: Are We Closing the Circle?
Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. On cell stress Bax and Bak accumulate at distinct foci on the mitochondrial surface where they undergo a conformational change, oligomerize, and mediate cytochrome c release, leading to cell death. The molecular me...
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| Published in: | Trends Cell Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898608/ https://ncbi.nlm.nih.gov/pubmed/27932064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2016.11.004 |
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