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Opa1-mediated cristae opening is Bax/Bak- and BH3-dependent, required for apoptosis, and independent of Bak oligomerization

Controversy surrounds the role and mechanism of mitochondrial cristae remodeling in apoptosis. Here we show that pro-apoptotic BH3-only proteins Bid and Bim induced full cytochrome c release but only a subtle alteration of crista junctions, which involved the disassembly of Opa1 complexes. Both mito...

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Библиографические подробности
Главные авторы: Yamaguchi, Ryuji, Lartigue, Lydia, Perkins, Guy, Scott, Ray T., Dixit, Amruta, Kushnareva, Yulia, Kuwana, Tomomi, Ellisman, Mark, Newmeyer, Donald D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636708/
https://ncbi.nlm.nih.gov/pubmed/18691924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.010
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