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Opa1-mediated cristae opening is Bax/Bak- and BH3-dependent, required for apoptosis, and independent of Bak oligomerization
Controversy surrounds the role and mechanism of mitochondrial cristae remodeling in apoptosis. Here we show that pro-apoptotic BH3-only proteins Bid and Bim induced full cytochrome c release but only a subtle alteration of crista junctions, which involved the disassembly of Opa1 complexes. Both mito...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636708/ https://ncbi.nlm.nih.gov/pubmed/18691924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.010 |
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