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Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
The mechanism by which the proapoptotic Bcl-2 family members Bax and Bak release cytochrome c from mitochondria is incompletely understood. In this paper, we show that activator BH3-only proteins bind tightly but transiently to the Bak hydrophobic BH3-binding groove to induce Bak oligomerization, li...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Rockefeller University Press
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135403/ https://ncbi.nlm.nih.gov/pubmed/21727192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201102027 |
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