Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

The mechanism by which the proapoptotic Bcl-2 family members Bax and Bak release cytochrome c from mitochondria is incompletely understood. In this paper, we show that activator BH3-only proteins bind tightly but transiently to the Bak hydrophobic BH3-binding groove to induce Bak oligomerization, li...

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Bibliografiska uppgifter
Huvudupphovsmän: Dai, Haiming, Smith, Alyson, Meng, X. Wei, Schneider, Paula A., Pang, Yuan-Ping, Kaufmann, Scott H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2011
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135403/
https://ncbi.nlm.nih.gov/pubmed/21727192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201102027
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