Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to initiate Bak homo-oligomerization. However, it is unclear how such tight binding can induce Bak homo-oligomerization. Here we report the ligand-induced Bak conformational cha...

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Bibliographic Details
Main Authors: Pang, Yuan-Ping, Dai, Haiming, Smith, Alyson, Meng, X. Wei, Schneider, Paula A., Kaufmann, Scott H.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277102/
https://ncbi.nlm.nih.gov/pubmed/22355769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00257
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