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Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance

Bcl-2 is phosphorylated on Ser(70) after treatment of cells with spindle poisons. Based on the cellular effects of overexpressing Bcl-2 S70E or S70A mutants, various studies have concluded that Ser(70) phosphorylation either enhances or diminishes Bcl-2 function. In the present study, the ability of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dai, Haiming, Ding, Husheng, Meng, X. Wei, Lee, Sun-Hee, Schneider, Paula A., Kaufmann, Scott H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910374/
https://ncbi.nlm.nih.gov/pubmed/24097825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0940
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