Characterization of an alternative BAK-binding site for BH3 peptides

Many cellular stresses are transduced into apoptotic signals through modification or up-regulation of the BH3-only subfamily of BCL2 proteins. Through direct or indirect mechanisms, these proteins activate BAK and BAX to permeabilize the mitochondrial outer membrane. While the BH3-only proteins BIM,...

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Publicado no:Nat Commun
Main Authors: Ye, Kaiqin, Meng, Wei X., Sun, Hongbin, Wu, Bo, Chen, Meng, Pang, Yuan-Ping, Gao, Jia, Wang, Hongzhi, Wang, Junfeng, Kaufmann, Scott H., Dai, Haiming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335050/
https://ncbi.nlm.nih.gov/pubmed/32620849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17074-y
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