Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

PCAF and ADA3 associate within the same macromolecular complexes to control the transcription of many genes, including some that regulate apoptosis. Here we show that PCAF and ADA3 regulate the expression of PACS1, whose protein product is a key component of the machinery that sorts proteins among t...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Brasacchio, Daniella, Alsop, Amber E, Noori, Tahereh, Lufti, Mariam, Iyer, Sweta, Simpson, Kaylene J, Bird, Phillip I, Kluck, Ruth M, Johnstone, Ricky W, Trapani, Joseph A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442465/
https://ncbi.nlm.nih.gov/pubmed/28060382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.119
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