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Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore

In mitochondrial apoptosis, Bak is activated by death signals to form pores of unknown structure on the mitochondrial outer membrane via homooligomerization. Cytochrome c and other apoptotic factors are released from the intermembrane space through these pores, initiating downstream apoptosis events...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mandal, Tirtha, Shin, Seungjin, Aluvila, Sreevidya, Chen, Hui-Chen, Grieve, Carter, Choe, Jun-Yong, Cheng, Emily H., Hustedt, Eric J., Oh, Kyoung Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973285/
https://ncbi.nlm.nih.gov/pubmed/27488021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30763
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