Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers

During apoptosis, the pro-apoptotic Bcl-2 family proteins BAK and BAX form large oligomeric pores in the mitochondrial outer membrane. Apoptotic factors, including cytochrome c, are released through these pores from the mitochondrial intermembrane space into the cytoplasm where they initiate the cas...

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Hlavní autoři: Oh, Kyoung Joon, Singh, Pawan, Lee, Kyungro, Foss, Kelly, Lee, Shinyoub, Park, Minji, Lee, Steffi, Aluvila, Sreevidya, Park, Matthew, Singh, Puja, Kim, Ryung-Suk, Symersky, Jindrich, Walters, D. Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937919/
https://ncbi.nlm.nih.gov/pubmed/20605789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135293
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