Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers

During apoptosis, the pro-apoptotic Bcl-2 family proteins BAK and BAX form large oligomeric pores in the mitochondrial outer membrane. Apoptotic factors, including cytochrome c, are released through these pores from the mitochondrial intermembrane space into the cytoplasm where they initiate the cas...

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Detalhes bibliográficos
Main Authors: Oh, Kyoung Joon, Singh, Pawan, Lee, Kyungro, Foss, Kelly, Lee, Shinyoub, Park, Minji, Lee, Steffi, Aluvila, Sreevidya, Park, Matthew, Singh, Puja, Kim, Ryung-Suk, Symersky, Jindrich, Walters, D. Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937919/
https://ncbi.nlm.nih.gov/pubmed/20605789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135293
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