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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x(L), but not Bcl-2, until displaced by BH3-only proteins

Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins trigger apoptosis by binding via their BH3 domain to prosurvival relatives, while the proapoptotic Bax and Bak have an...

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Detalhes bibliográficos
Main Authors: Willis, Simon N., Chen, Lin, Dewson, Grant, Wei, Andrew, Naik, Edwina, Fletcher, Jamie I., Adams, Jerry M., Huang, David C.S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142553/
https://ncbi.nlm.nih.gov/pubmed/15901672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1304105
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