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Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like relatives. Loss of individual BH3-only proteins can lead either to no phenotype, as in mice lacking Bik, or to marked cell excess, as in the hematopoietic compartment of animals lacking Bim. To investigat...

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Bibliografiske detaljer
Main Authors: Coultas, Leigh, Bouillet, Philippe, Loveland, Kate L, Meachem, Sarah, Perlman, Harris, Adams, Jerry M, Strasser, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283956/
https://ncbi.nlm.nih.gov/pubmed/16270031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600857
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