Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim

Osteoclasts (OCs) undergo rapid apoptosis without trophic factors, such as macrophage colony-stimulating factor (M-CSF). Their apoptosis was associated with a rapid and sustained increase in the pro-apoptotic BH3-only Bcl-2 family member Bim. This was caused by the reduced ubiquitylation and proteas...

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Autori principali: Akiyama, Toru, Bouillet, Phillippe, Miyazaki, Tsuyoshi, Kadono, Yuho, Chikuda, Hirotaka, Chung, Ung-il, Fukuda, Akira, Hikita, Atsuhiko, Seto, Hiroaki, Okada, Takashi, Inaba, Toshiya, Sanjay, Archana, Baron, Roland, Kawaguchi, Hiroshi, Oda, Hiromi, Nakamura, Kozo, Strasser, Andreas, Tanaka, Sakae
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC291830/
https://ncbi.nlm.nih.gov/pubmed/14657036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg635
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