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JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

Abstract Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JAK) inhibitors have been shown to successfully ameliorate arthritis-rela...

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Principais autores: Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-03-01
coleção:Inflammation and Regeneration
Assuntos:
JAK inhibitor
Osteoclast
Intravital imaging
Inflammatory bone destruction
Cell migration
Chemokine
Acesso em linha:https://doi.org/10.1186/s41232-023-00268-4
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