JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

Abstract Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JAK) inhibitors have been shown to successfully ameliorate arthritis-rela...

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Bibliografische Detailangaben

Hauptverfasser:	Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-03-01
Schriftenreihe:	Inflammation and Regeneration
Schlagworte:	JAK inhibitor Osteoclast Intravital imaging Inflammatory bone destruction Cell migration Chemokine
Online-Zugang:	https://doi.org/10.1186/s41232-023-00268-4
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