Proapoptotic BH3-Only Bcl-2 Family Member Bik/Blk/Nbk Is Expressed in Hemopoietic and Endothelial Cells but Is Redundant for Their Programmed Death

The BH3-only members of the Bcl-2 protein family are essential for initiation of programmed cell death and stress-induced apoptosis. We have determined the expression pattern in mice of the BH3-only protein Bik, also called Blk or Nbk, and examined its physiological function by gene targeting. We fo...

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Autores principales: Coultas, Leigh, Bouillet, Philippe, Stanley, Edouard G., Brodnicki, Thomas C., Adams, Jerry M., Strasser, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC344198/
https://ncbi.nlm.nih.gov/pubmed/14749373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1570-1581.2004
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