The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains controversial. The indirect activation model suggests that they simply must neutralize all of the prosurvival Bcl-2 family members, whereas the direct...

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Detalhes bibliográficos
Main Authors: Mérino, Delphine, Giam, Maybelline, Hughes, Peter D., Siggs, Owen M., Heger, Klaus, O'Reilly, Lorraine A., Adams, Jerry M., Strasser, Andreas, Lee, Erinna F., Fairlie, Walter D., Bouillet, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728397/
https://ncbi.nlm.nih.gov/pubmed/19651893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200905153
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